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Study population is quite diverse as affected participants are from all over the world. Is willing to allow storage of biological specimens for future use in medical research. Is willing to allow genetic testing on collected biological samples. Has a primary care or other physician who will manage all health conditions related or unrelated to the study objectives.

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Please refer to this study by its ClinicalTrials. Individuals must have a past or present history of one of the clinical and one of the laboratory characteristics mentioned above to be considered for study enrollment. Individuals must have past or present history one or more of the following to be considered for study flr Evidence of systemic inflammation eg, ESR or CRP Cytopenias eg.

Is willing to allow storage of biological specimens for future use in medical research. Study population is quite diverse as affected participants are from all over the world.

Is willing to allow storage of biological samples for future use in medical research. Participants must meet both of the following criteria: Clinical characteristics strongly consistent with an IL-1 mediated autoinflammatory disease per the following criteria and at the discretion of the principal investigator PI. Be related by blood to zolotogorsiky affected participant.

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Has clinical s or symptoms not explained by any other disorder eg, infections, malignancies and are consistent with a possible IFN-mediated, autoinflammatory disease. Individuals with defined organ inflammation associated with past or current evidence of systemic inflammation.

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Does not fulfill any of inclusion criterion 5 for affected participants. Oncological evaluation suggestive of lymphoma, leukemia or multiple myeloma, except for participants with a known primary diagnosis of an autoinflammatory disease who subsequently developed a malignancy.

Has a primary care or other physician who will manage all health conditions related or unrelated to the study objectives. Has clinical s or symptoms not explained by any other disorder eg, infections, malignancies and are consistent with a possible IL-1 mediated autoinflammatory disease.

Not be related to an affected participant. Is willing to allow genetic testing on collected biological samples.

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Individuals must have a past or present history of one of the following to be considered for study enrollment: Recurrent fevers that has gone undiagnosed after reasonable attempts, and that is consistent with the conditions under study in this protocol Panniculitis, ischemic ulcerative skin lesions, chilblain lesions, or livedo reticularis Lipodystrophy Myositis, arthralgias, arthritis, or t contractures Basal ganglia calcifications or white matter CNS disease Interstitial lung disease, lung fibrosis, or pulmonary hypertension Conjunctivitis, episcleritis, cortical blindness, glaucoma, papilledema, or hepatosplenomegaly Laboratory characteristics strongly consistent with an IFN-mediated autoinflammatory disease per the following criteria.

Participants must meet one of the following criteria: Clinical characteristics strongly consistent with an undifferentiated autoinflammatory disease.

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These patients will not be excluded from the study.